IRN-MLSQR: An improved iterative reweight norm approach to the inverse problem of electrocardiography incorporating...

The inverse problem of electrocardiography (ECG) of computing epicardial potentials from body surface potentials, is an ill-posed problem and needs to be solved by regularization techniques. The L2-norm regularization can cause considerable smoothing of the solution, while the L1-norm scheme promotes a solution with sharp boundaries/gradients between piecewise smooth regions, so L1-norm is widely used in the ECG inverse problem. However, large amount of computation and long computation time are needed in the L1-norm scheme. In this paper, by combining iterative reweight norm (IRN) with a factorization-free preconditioned LSQR algorithm (MLSQR), a new IRN-MLSQR method was proposed to accelerate the convergence speed of the L1-norm scheme. We validated the IRN-MLSQR method using experimental data from isolated canine hearts and clinical procedures in the electrophysiology laboratory. The results showed that the IRN-MLSQR method can significantly reduce the number of iterations and operation time while ensuring the calculation accuracy. The number of iterations of the IRN-MLSQR method is about 60%-70% that of the conventional IRN method, and at the same time, the accuracy of the solution is almost the same as that of the conventional IRN method. The proposed IRN-MLSQR method may be used as a new approach to the inverse problem of ECG.