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Pediatric Tuberculosis: The Impact of "Omics" on Diagnostics Development
Shailja Jakhar1, Alexis A Bitzer1, Loreen R Stromberg1
1Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Insights
Pediatric tuberculosis diagnosis needs better biomarkers. The "omics" approach shows promise for developing rapid, point-of-care diagnostics to improve early identification and treatment monitoring in children.
Area of Science:
- Infectious Diseases
- Biomarker Discovery
- Pediatric Health
Background:
- Tuberculosis (TB) poses a significant global health challenge.
- Pediatric TB diagnosis is particularly difficult due to a lack of validated biomarkers.
- Early identification and monitoring of treatment response in children remain critical unmet needs.
Purpose of the Study:
- To review the impact of
Main Methods:
- Literature review focusing on
Main Results:
- The
Conclusions:
- The
Abstract:
Tuberculosis (TB) is a major public health concern for all ages. However, the disease presents a larger challenge in pediatric populations, partially owing to the lack of reliable diagnostic standards for the early identification of infection. Currently, there are no biomarkers that have been clinically validated for use in pediatric TB diagnosis. Identification and validation of biomarkers could provide critical information on prognosis of disease, and response to treatment. In this review, we discuss how the "omics" approach has influenced biomarker discovery and the advancement of a next generation rapid point-of-care diagnostic for TB, with special emphasis on pediatric disease. Limitations of current published studies and the barriers to their implementation into the field will be thoroughly reviewed within this article in hopes of highlighting future avenues and needs for combating the problem of pediatric tuberculosis.
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