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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Updated: Dec 7, 2025

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Mapping TRPM7 Function by NS8593.

Vladimir Chubanov1, Thomas Gudermann1

  • 1Walther-Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians Universität München, 80336 Munich, Germany.

International Journal of Molecular Sciences
|September 26, 2020
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) is crucial for development and ion balance. The compound NS8593 effectively mimics TRPM7 genetic inactivation, aiding drug development for diseases.

Keywords:
NS8593TRPM7calciummagnesiumnaltribenzinc

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Area of Science:

  • Molecular Biology
  • Pharmacology
  • Physiology

Background:

  • TRPM7 is a vital membrane protein with channel and kinase functions, essential for embryonic development and ion homeostasis.
  • TRPM7 dysfunction is linked to various diseases, including anoxic neuronal death, fibrosis, and cancer, making it a therapeutic target.

Purpose of the Study:

  • To review the progress in assessing TRPM7 druggability.
  • To highlight the utility of the TRPM7 inhibitor NS8593 in preclinical research.

Main Methods:

  • Summarizing research on pharmacological modulators of TRPM7.
  • Analyzing studies that used NS8593 to investigate TRPM7 function and therapeutic potential.

Main Results:

  • NS8593 treatment effectively replicates phenotypes observed in cells with genetic TRPM7 inactivation.
  • NS8593 has proven useful in animal models for evaluating TRPM7-based therapies for human diseases.

Conclusions:

  • NS8593 is a valuable tool for studying TRPM7's role in cellular pathways.
  • Studies using NS8593 provide a framework for preclinical assessment of TRPM7-targeting drugs.