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Thermogenic potentials of bone marrow adipocytes
Meshail Okla1, Moustapha Kassem2
1Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Bone
|September 26, 2020
Summary
Bone marrow adipose tissue (MAT) can undergo browning, a process that may help prevent its detrimental expansion in conditions like obesity. Understanding MAT
Area of Science:
- Endocrinology and Metabolism
- Bone Biology
- Adipose Tissue Biology
Background:
- Bone marrow adipose tissue (MAT) is a unique fat depot adjacent to bone, influencing skeletal regulation.
- MAT quantity changes with energy status, expanding in obesity and anorexia nervosa, negatively impacting bone health.
- MAT exhibits characteristics of both white and brown adipose tissues, with distinct metabolic and insulin sensitivity profiles.
Purpose of the Study:
- To review the phenomenon of MAT browning and its regulation.
- To explore the relationship between adaptive thermogenesis and bone health.
- To highlight the potential of MAT thermogenesis for improving bone and metabolic health.
Main Methods:
- Literature review of studies on MAT browning.
- Analysis of regulatory mechanisms of MAT browning in pathophysiological conditions.
- Discussion of the link between thermogenesis and bone health.
Main Results:
- MAT can undergo browning, a process potentially counteracting excessive accumulation.
- Pathophysiological conditions influence MAT browning.
- Thermogenic potential of MAT is linked to bone health and whole-body energy metabolism.
Conclusions:
- MAT browning is a key area for investigation.
- Understanding MAT thermogenesis offers therapeutic potential for bone and metabolic disorders.
- Further research into MAT's role in thermogenesis is warranted.
