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Progress of long noncoding RNAs in anti-tumor resistance

Hui Zhang1, Yuanyuan Wang2, Xiaomin Liu1

  • 1Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, 200444, China.

Pathology, Research and Practice
|September 26, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) play a crucial role in cancer drug resistance. Understanding lncRNA mechanisms is key to overcoming treatment failure and improving long-lasting cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer drug resistance is a major cause of treatment failure.
  • Long non-coding RNAs (lncRNAs) are non-protein-coding RNA molecules involved in gene regulation.
  • lncRNAs are increasingly recognized for their role in tumor development and drug resistance.

Purpose of the Study:

  • To review recent research on lncRNAs in various cancer drug resistances.
  • To elucidate the mechanisms by which lncRNAs influence anti-tumor drug resistance.

Main Methods:

  • Literature review of recent studies on lncRNA and cancer drug resistance.
  • Analysis of reported mechanisms of lncRNA action in tumor resistance.

Main Results:

  • Abnormal lncRNA expression is linked to the development of resistance in tumor cells.
  • lncRNAs impact multiple types of anti-tumor drug resistance.
  • Specific lncRNAs have been identified as regulators of drug resistance pathways.

Conclusions:

  • lncRNAs are significant regulators of cancer drug resistance.
  • Targeting lncRNAs presents a potential strategy for overcoming drug resistance.
  • Further research into lncRNA mechanisms can lead to more effective cancer treatments.
Keywords:
CancerDrug resistanceLong noncoding RNAMolecular mechanism

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