Oxybutynin in primary hyperhidrosis: A long-term real-life study

Area of Science:

• Dermatology
• Pharmacology

Background:

• Hyperhidrosis is excessive sweating impacting quality of life.
• Current treatments may have limitations or side effects.

Purpose of the Study:

• To evaluate the effectiveness, tolerance, and safety of oral oxybutynin for hyperhidrosis.
• To assess long-term outcomes in a real-life setting.

Main Methods:

• A long-term study involving 30 patients with primary hyperhidrosis (HDSS score ≥ 2).
• Patients completed questionnaires on demographics, HDSS scores, and oxybutynin side effects.
• Treatment duration ranged from 1 to 6 years.

Main Results:

• Significant improvement in Hyperhidrosis Disease Severity Scale (HDSS) scores (P < .001).
• Most common forms of hyperhidrosis included axillary, palmoplantar, and cranio-facial.
• Treatment was generally well-tolerated with mild side effects.

Conclusions:

• Oral oxybutynin is an effective and safe treatment option for hyperhidrosis in both pediatric and adult populations.
• Long-term use of oxybutynin demonstrates sustained efficacy and acceptable safety profile.
• Oxybutynin offers a viable therapeutic strategy for improving patient quality of life affected by hyperhidrosis.