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Updated: Jul 25, 2026
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Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications
Published on: June 29, 2020
14.3K
[New aspects of rabies control]
H Bourhy1, G D de Melo1, A Tarantola1
1Unité lyssavirus, épidémiologie et neuropathologie, centre collaborateur de l'Organisation mondiale de la santé de référence et de recherche sur la rage, institut Pasteur, 28, rue du Docteur Roux, 75724 Paris cedex 15, France.
Bulletin De L'Academie Nationale De Medecine
|September 28, 2020
Summary
Rabies prevention has improved, but post-exposure treatments remain costly and inaccessible. New approaches and targeted dog vaccination strategies are crucial for reducing human rabies deaths.
Area of Science:
- Veterinary Public Health
- Infectious Disease Epidemiology
- Vaccinology
Context:
- Rabies causes approximately 60,000 human deaths annually, predominantly in impoverished regions of Africa and Asia.
- While rabies vaccines have advanced since Pasteur's innovation, post-exposure prophylaxis (PEP) remains lengthy and expensive.
- Current PEP involves vaccine combined with rabies immunoglobulins, which are costly and scarce in developing nations.
Purpose:
- To review advancements in rabies post-exposure prophylaxis (PEP) and explore novel strategies for improved accessibility and cost-effectiveness.
- To highlight the challenges and potential of mass dog vaccination campaigns in preventing human rabies.
- To emphasize the importance of understanding epidemiological drivers for optimizing rabies control in canine populations.
Summary:
- Significant progress in rabies prophylaxis exists, yet current protocols involving vaccines and immunoglobulins are burdensome and inaccessible in many regions.
- Innovative approaches are emerging to address the cost and availability issues of rabies serotherapy.
- Mass dog vaccination, a key strategy for human rabies prevention, faces implementation hurdles and variable effectiveness, necessitating better understanding of disease transmission dynamics.
Impact:
- Development of more accessible and affordable rabies post-exposure prophylaxis, potentially saving thousands of lives annually.
- Improved strategies for mass dog vaccination, leading to reduced rabies virus circulation in canine populations and decreased human exposure.
- Enhanced understanding of rabies epidemiology to guide targeted interventions and optimize control programs in endemic areas.
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