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Updated: Dec 7, 2025
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
Published on: May 24, 2019
A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes
Huizhen Wang1, Kejing Wan, Yue Zhou
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China. xiaoxiaohe@hnu.edu.cn hedinggeng@hnu.edu.cn kmwang@hnu.edu.cn.
Abstract:
A three-dimensional (3D) multipedal DNA walker triggered by the specific recognition between aptamers and proteins was developed for ultrasensitive tumor exosome sensing. A detection limit of 1 particle μL-1 was obtained with high selectivity. With the advantages of being simple, cost-effective and ultrasensitive, the biosensor offers potential for the early clinical diagnosis of tumors.
