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Multiple meningiomas: does quantity matter? a population-based survival analysis with underlined age and sex

Andres Ramos-Fresnedo1, Ricardo A Domingo1, Tito Vivas-Buitrago1

  • 1Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, USA.

Journal of Neuro-Oncology
|September 28, 2020
PubMed
Abstract

Insights

The number of intracranial meningiomas significantly impacts overall survival, with more lesions leading to worse outcomes. Female patients experience increased survival and a lower risk of developing meningiomatosis (MM).

Area of Science:

  • Neurosurgery
  • Oncology
  • Epidemiology

Background:

  • Meningiomatosis (MM), characterized by multiple intracranial meningiomas, is rare and poorly understood.
  • Existing literature on MM primarily consists of limited case series and individual reports, hindering survival outcome analysis.

Observation:

  • This study analyzed data from 99,918 patients diagnosed with meningiomas between 1975 and 2017 using the SEER database.
  • The analysis focused on the impact of lesion number, patient age, and sex on overall survival (OS).

Findings:

  • Meningiomatosis patients exhibited significantly decreased overall survival compared to those with a single lesion (94 vs. 180 months).
  • A progressive decrease in OS was observed with an increasing number of lesions (2, 3, or ≥4 lesions).
  • Female patients demonstrated improved OS (HR 0.778) and a reduced risk of developing MM (HR 0.809).

Implications:

  • The number of meningiomas is a critical prognostic factor, with each additional lesion negatively affecting survival.
  • Female sex is associated with better outcomes and a lower incidence of meningiomatosis.
  • These findings highlight the importance of considering lesion burden and sex in managing patients with meningiomatosis.
Keywords:
MeningiomatosisMultiple meningiomasNational databaseSEERSexSurvival

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