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Analysis of Bone Tissue Condition in Patients with Diffuse Large B-Cell Lymphoma without Bone Marrow Involvement
E A Fastova1, A U Magomedova2, S K Kravchenko2
1National Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia. fastova12@gmail.com.
Bulletin of Experimental Biology and Medicine
|September 28, 2020
Summary
Diffuse large B-cell lymphoma impacts bone tissue, altering gene expression in stromal cells. While bone resorption markers were elevated initially, remission leads to age-appropriate bone health through compensatory mechanisms.
Area of Science:
- Oncology
- Bone Metabolism
- Hematology
Background:
- Diffuse large B-cell lymphoma (DLBCL) can affect bone health.
- Understanding bone tissue changes in DLBCL patients is crucial for long-term management.
Purpose of the Study:
- To investigate bone tissue alterations in DLBCL patients at diagnosis and long-term post-treatment.
- To analyze gene expression in bone marrow stromal cells and correlate with osteoporosis markers.
Main Methods:
- Osteodensitometry was performed on patients.
- Biochemical markers of osteoporosis in blood and urine were analyzed.
- Gene expression profiling of multipotent mesenchymal stromal cells was conducted.
Main Results:
- Altered expression of bone/cartilage differentiation genes (FGF2, FGFR1, FGFR2, BGLAP, SPP1, TGFB1, SOX9) was observed in stromal cells.
- Elevated urine deoxypyridinoline/creatinine and serum β-cross-laps, with reduced vitamin D, indicated bone resorption activation in primary patients.
- Osteodensitometry showed no significant group differences.
Conclusions:
- DLBCL affects bone marrow stroma, influencing bone and cartilage differentiation genes.
- Remission and compensatory mechanisms contribute to age-appropriate bone tissue condition post-treatment.
- No direct correlation was found between stromal cell gene expression changes and osteoporosis markers.
