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Aquagenic keratoderma with dorsal involvement treated with botulinum toxin. Case report and review of literature

Ana Rodríguez-Villa Lario1, David Vega-Díez1, Marta González-Cañete1

  • 1Department of Dermatology, Príncipe de Asturias University Hospital, Madrid, Spain.

Dermatologic Therapy
|September 28, 2020
PubMed
Abstract

No abstract available in PubMed .

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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...