Cutaneous lesions and mitochondrial hearing loss: A case report
Ester Moreno-Artero1, Teresa Imizcoz2, Carlos Prieto3
1Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Pediatric Dermatology
|December 16, 2022
Abstract:
Pathogenic sequence changes in mitochondrial DNA (mtDNA) are one of the most common causes of genetic hearing loss. We report an infant with palmoplantar hyperkeratosis, extrapalmoplantar cutaneous features and mitochondrial sensorineural hearing loss caused by the previously reported pathogenic NC_012920:m.7445A > G sequence change in the mitochondrial gene COX1 (COX1, MT-CO1). Next generation sequencing- based technology was key for the diagnosis and management of this patient.
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