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Coffee Consumption and Pancreatic Cancer Risk: A Meta-Epidemiological Study of Population-based Cohort Studies
Jong-Myon Bae1, Sung Ryul Shim2
1Department of Preventive Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
Asian Pacific Journal of Cancer Prevention : APJCP
|September 28, 2020
Summary
Coffee consumption does not appear to increase pancreatic cancer risk. This meta-analysis found no significant association, even with dose-response analysis, suggesting coffee is safe regarding pancreatic cancer incidence.
Area of Science:
- Epidemiology
- Oncology
- Nutritional Science
Background:
- Previous systematic reviews on coffee consumption and pancreatic cancer yielded inconsistent findings.
- Further investigation is needed to clarify the association between coffee intake and pancreatic cancer incidence.
Purpose of the Study:
- To conduct a meta-epidemiological study to explore the association between coffee consumption and pancreatic cancer incidence.
- To resolve inconsistencies from prior systematic reviews.
Main Methods:
- A meta-analysis of population-based prospective cohort studies was performed.
- Data on adjusted relative risk (RR) and 95% confidence intervals (95%CI) for pancreatic cancer were extracted.
- Fixed-effect and two-stage random-effects dose-response meta-analysis (DRMA) models were applied.
Main Results:
- Twelve cohort studies comprising over 3.2 million participants were analyzed.
- No statistically significant association was found between the highest versus lowest coffee consumption levels and pancreatic cancer risk (sRR=0.98, 95% CI: 0.88-1.10).
- DRMA indicated no significant linear or non-linear dose-response relationship between coffee consumption and pancreatic cancer risk (RR per cup/day=0.97, 95%CI: 0.91-1.04).
Conclusions:
- Coffee consumption habits are not associated with an increased risk of pancreatic cancer.
- No statistically significant dose-response relationship exists between coffee intake and pancreatic cancer risk.
- Identifying potential thresholds for coffee consumption may be relevant for pancreatic cancer prevention strategies.
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