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Obstructive Sleep Apnea and Risk of COVID-19 Infection, Hospitalization and Respiratory Failure
Matthew B Maas1,2,3, Minjee Kim4,5, Roneil G Malkani5,6
1Division of Stroke and Neurocritical Care, Department of Neurology, Northwestern University, 625 N Michigan Ave, Suite 1150, Chicago, IL, 60611, USA. mbmaas@northwestern.edu.
Sleep & Breathing = Schlaf & Atmung
|September 29, 2020
Summary
Obstructive Sleep Apnea (OSA) significantly increases the risk of COVID-19 infection and severe outcomes like hospitalization and respiratory failure. Individuals with OSA face a higher likelihood of severe COVID-19 progression.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Epidemiology
Background:
- Obstructive Sleep Apnea (OSA) is a common condition affecting respiratory health.
- The impact of OSA on COVID-19 susceptibility and severity requires further investigation.
Purpose of the Study:
- To examine the association between OSA and the risk of COVID-19 infection.
- To assess the relationship between OSA and COVID-19 disease severity, including hospitalization and respiratory failure.
Main Methods:
- A retrospective cohort study using electronic medical records from a large healthcare system.
- COVID-19 cases were identified, and outcomes (hospitalization, respiratory failure) were analyzed.
- Logistic regression adjusted for diabetes, hypertension, and BMI to evaluate OSA's independent risk.
Main Results:
- OSA prevalence was higher in hospitalized COVID-19 patients and those with respiratory failure.
- Unadjusted analysis showed OSA associated with a 5-fold increased risk for hospitalization and respiratory failure.
- Adjusted analysis revealed OSA increased hospitalization risk (OR 1.65) and respiratory failure risk (OR 1.98).
Conclusions:
- OSA is linked to an approximately 8-fold higher risk of COVID-19 infection.
- Among COVID-19 patients, OSA significantly elevates the risk of hospitalization and respiratory failure.
- OSA represents a critical comorbidity influencing COVID-19 outcomes.
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