Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.2K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.2K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overexpression of Circular RNA circTTN Promotes Ferroptosis in Sepsis-Induced Cardiomyopathy.

Journal of cellular and molecular medicine·2026
Same author

Glycolysis: The Bridge Between Cellular Interaction and Alzheimer's Disease.

Biomolecules·2026
Same author

Evaluation of Different Strategies to Incorporate Absolute Abundance into Habitat Selection Modeling for the Endangered <i>Cheirotonus jansoni</i>.

Insects·2026
Same author

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High-Performance Cu Alloys.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

High-Altitude Hypoxic Preconditioning Attenuates Lipopolysaccharide-Induced Lung Injury and is Associated with Alveolar-Capillary Barrier Maintenance.

Journal of inflammation research·2026
Same author

Application of an artificial-intelligence-based transesophageal echocardiography simulation system in residency training.

Frontiers in surgery·2026
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Dec 7, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.6K

TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function.

Si-Yi Chen1, Tao Yue1, Qian Lei1

  • 1Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology; Wuhan, 430074, China.

Nucleic Acids Research
|September 29, 2020
PubMed
Summary
This summary is machine-generated.

TCRdb is a new database of over 277 million human T-cell receptor (TCR) sequences from diverse samples. This resource facilitates the reuse of T-cell receptor sequencing data for immunological research.

More Related Videos

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

9.9K
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

11.7K

Related Experiment Videos

Last Updated: Dec 7, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.6K
Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

9.9K
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

11.7K

Area of Science:

  • Immunology
  • Bioinformatics
  • Genomics

Background:

  • T cells and their T-cell receptor (TCR) repertoire are crucial for immune responses and immunotherapy.
  • TCR sequencing (TCR-Seq) technology allows for accurate profiling of the TCR repertoire, with extensive public data available.
  • Effective reuse of existing TCR-Seq data is essential for advancing T cell immunology research.

Purpose of the Study:

  • To develop TCRdb, a comprehensive database of human TCR sequences.
  • To standardize the characterization of TCR sequences from TCR-Seq data using a uniform pipeline.
  • To create a valuable resource for researchers studying T cell immunology.

Main Methods:

  • Collected and processed a large dataset of TCR-Seq data.
  • Developed and applied a strict, uniform pipeline for TCR sequence characterization.
  • Integrated over 277 million high-quality TCR sequences from more than 8265 TCR-Seq samples.
  • Organized data with categorized sample metadata and developed interactive visualization tools.

Main Results:

  • Established TCRdb, a database containing over 277 million reliable human TCR sequences.
  • Included data from over 8265 TCR-Seq samples across diverse tissues, clinical conditions, and cell types.
  • Implemented features for powerful sequence searching, sample comparison, and data visualization (TCR diversity, length distribution, V-J gene utilization).

Conclusions:

  • TCRdb provides a comprehensive and reliable resource for human TCR repertoire analysis.
  • The database's features enable efficient identification and comparison of TCR sequences across various conditions.
  • TCRdb is freely available and poised to become a significant resource for the T cell immunology research community.