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Updated: Dec 7, 2025

A Two-interval Forced-choice Task for Multisensory Comparisons
Published on: November 9, 2018
Power calculations for the sequential parallel comparison design with continuous outcomes
Anastasia Ivanova1, Bahjat Qaqish1
1Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Abstract:
In the sequential parallel comparison design (SPCD) in stage 1, placebo subjects are randomized between placebo and an experimental therapy. In stage 2, stage 1 placebo non-responders are re-randomized between placebo and an experimental therapy. We give the formula for power/sample size calculations for two test statistics for the SPCD. The first one omits the correlation between the estimated treatment effects from the two stages, and the second one does not. We discuss how to construct a confidence interval for the weighted average of the treatment effects that has proper coverage.
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