Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

747
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
747
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

465
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
465
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

646
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
646
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.3K
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

196
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
196
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

611
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
611

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional Analgesia for Truncal Surgeries: Reply.

Anesthesiology·2026
Same author

Botulinum toxin type A for subacute/chronic neck pain.

The Cochrane database of systematic reviews·2026
Same author

Satisfaction and Persistent Pain Outcomes After Knee Arthroplasty: A Prospective Cohort Study.

The Journal of arthroplasty·2026
Same author

Society for Ambulatory Anesthesia Position Statement on Risk Assessment and Prophylaxis for Prevention of Venous Thromboembolism After Ambulatory Surgery: A Simplified Approach.

Anesthesia and analgesia·2026
Same author

Importance of early postoperative mobilization: comprehensive review.

BJS open·2026
Same author

Development of risk prediction model for chronic pain after knee replacement surgery: protocol for an individual patient data meta-analysis.

Perioperative medicine (London, England)·2026

Related Experiment Video

Updated: Dec 7, 2025

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.0K

Perioperative Opioid Administration.

Harsha Shanthanna, Karim S Ladha, Henrik Kehlet

    Anesthesiology
    |September 29, 2020
    PubMed
    Summary
    This summary is machine-generated.

    Opioid-free anesthesia strategies may not be fully supported by current evidence, lacking analgesic titration and clarity on optimal components. These approaches may not reduce long-term opioid risks.

    More Related Videos

    An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
    14:56

    An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

    Published on: January 27, 2010

    21.8K
    Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
    09:43

    Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons

    Published on: May 25, 2015

    18.0K

    Related Experiment Videos

    Last Updated: Dec 7, 2025

    Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
    05:39

    Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

    Published on: May 26, 2023

    2.0K
    An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
    14:56

    An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

    Published on: January 27, 2010

    21.8K
    Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
    09:43

    Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons

    Published on: May 25, 2015

    18.0K

    Area of Science:

    • Anesthesiology
    • Pain Management
    • Pharmacology

    Background:

    • Opioids are crucial for general anesthesia and perioperative pain relief.
    • Discharge opioid prescriptions contribute to persistent opioid use and diversion.
    • Opioid-free strategies are gaining traction, often involving continuous infusions of analgesics and adjuvants.

    Purpose of the Study:

    • To critically review perioperative opioid use.
    • To compare opioid-sparing versus opioid-free strategies.
    • To evaluate the limitations and clinical considerations of opioid-free approaches.

    Main Methods:

    • Critical review of existing literature on perioperative opioid use.
    • Analysis of data regarding opioid-sparing and opioid-free anesthesia strategies.
    • Examination of clinical practice considerations and evidence gaps.

    Main Results:

    • Opioid-free strategies have limitations and gaps in current evidence.
    • These strategies lack analgesic titration based on patient needs.
    • Optimal components and roles in various surgical settings remain unclear.
    • Opioid-free strategies may not decrease the risk of persistent opioid use.

    Conclusions:

    • Current opioid-free strategies require further validation and refinement.
    • Addressing limitations is crucial for optimizing pain management and minimizing long-term harms.
    • A balanced approach considering opioid-sparing may be more realistic in certain contexts.