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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

129
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
129
Drug Therapy01:28

Drug Therapy

184
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
184
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

130
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
130
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

94
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
94
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

110
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
110
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

111
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
111

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Updated: Dec 7, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Polypharmacy and mobility outcomes.

Muhammad Usman Ali1, Diana Sherifali2, Donna Fitzpatrick-Lewis2

  • 1McMaster Evidence Review and Synthesis Team, McMaster University, 1280 Main St. W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada.

Mechanisms of Ageing and Development
|September 29, 2020
PubMed
Summary
This summary is machine-generated.

Deprescribing interventions effectively manage mobility issues in older adults with polypharmacy. This review shows reducing medications improves outcomes for community-dwelling seniors experiencing falls and functional decline.

Keywords:
Chronic diseaseMobilityMulti-morbidityOlder adultsPolypharmacy

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Area of Science:

  • Gerontology
  • Pharmacology
  • Public Health

Background:

  • Polypharmacy, the concurrent use of multiple medications, is prevalent in older adults.
  • It is linked to adverse outcomes, including falls, functional decline, and disability, particularly in mobility-related conditions.

Purpose of the Study:

  • To systematically review the effectiveness of deprescribing interventions.
  • To assess the impact on mobility-related conditions in community-dwelling older adults using five or more medications daily.

Main Methods:

  • Systematic literature review.
  • Analysis of studies reporting on deprescribing interventions and mobility outcomes in older adults.

Main Results:

  • Deprescribing interventions demonstrate effectiveness in addressing mobility-related issues.
  • Positive impacts observed on falls, functional status, and disability in the target population.

Conclusions:

  • Deprescribing is a valuable strategy for improving mobility and reducing adverse events in older adults with polypharmacy.
  • Further research and clinical implementation of deprescribing are warranted.