Working memory training impacts neural activity during untrained cognitive tasks in people with multiple sclerosis

The identification of effective cognitive rehabilitation strategies for people with multiple sclerosis (MS) is critically important, as cognitive difficulties are prevalent in MS. Relatively few cognitive rehabilitation studies in MS have examined working memory (WM) training specifically, and the extent that WM training may impact neural activity on untrained tasks is not well understood. In the present study, we examined the effects of 20 sessions of adaptive WM training (using an n-back task with visually presented letter stimuli) on neural indices of the transfer of training gains to untrained tasks in MS and healthy control participants. Event-Related Potential (ERP) measures were obtained before (pretest) and after training (posttest) on untrained visual tasks of spatial WM (Spatial 3-back task), cognitive control (Go/Nogo Flanker task), and processing speed and selective attention (Search task). At posttest compared to pretest, MS and control groups exhibited enhancement of N1 amplitude for the Spatial 3-back; attenuation of P2 amplitude, and enhancement of N2 amplitude for the Go/NoGo Flanker task; and enhancement of P2 and N2 amplitude for the Search task. These findings suggest that MS participants had enhancement of attention and cognitive control on untrained tasks following WM training that was similar to the effects that were observed in controls. In contrast, only the control group exhibited pretest-to-posttest enhancement of a late positive potential on the Spatial 3-back, as well as enhancement of P3 amplitude across all of the untrained outcome tasks. These latter findings suggest that there may be potential limitations in the neural plasticity induced by WM training in MS. Overall, the present study identified neural indices of the transfer of WM training gains that were responsive in MS and potentially resilient to disease processes, as well as those that were not.