Randomised controlled trial of Compensatory Cognitive Training and a Computerised Cognitive Remediation programme

Area of Science:

• Neuroscience
• Psychiatry
• Clinical Psychology

Background:

• Cognitive deficits are a core feature of schizophrenia spectrum disorders, impacting community functioning.
• Compensation and adaptation therapies aim to improve neurocognition and functional outcomes.
• Various delivery methods for these therapies have demonstrated effectiveness.

Purpose of the Study:

• To compare the efficacy of Compensatory Cognitive Training (CCT) and Computerised Interactive Remediation of Cognition-Training for Schizophrenia (CIRCuiTS).
• To investigate if mismatch negativity (MMN) can predict treatment response to cognitive interventions.
• To evaluate the impact of these interventions on neurocognition and social functioning.

Main Methods:

• A randomized controlled trial involving 100 clinically stable patients with schizophrenia spectrum disorders.
• Participants aged 18-65 years were randomized to either CCT or CIRCuiTS therapy groups.
• Outcome measures included neurocognition (BACS), subjective cognitive impairment (SSTICS), social functioning (SFS), and MMN (EEG).

Main Results:

• This section is to be filled once the study results are available.

Conclusions:

• The trial will determine if different cognitive intervention approaches offer comparable benefits for schizophrenia spectrum disorders.
• Findings will inform the practical implementation of cognitive interventions in routine clinical settings, considering cost and technology limitations.
• The study will contribute to understanding MMN's role as a predictor for cognitive intervention response.