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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Malignant phyllodes tumor with extensive lipomatous differentiation.

Jeffrey Landy1, Priya Johal1, Alexander Sevrukov1

  • 1Thomas Jefferson University Hospital, 111 S. 11th St., Philadelphia, PA 19107.

Radiology Case Reports
|September 30, 2020
PubMed
Summary

Malignant phyllodes tumors of the breast are rare. This case highlights extensive lipomatous differentiation, appearing as a fat-containing mass on imaging, which is an uncommon stromal alteration.

Keywords:
FibroadenomaHamartomaLipomatous differentiationPhyllodes

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Phyllodes tumors are uncommon fibroepithelial neoplasms of the breast.
  • Malignant phyllodes tumors represent a subset with potential for aggressive behavior.

Observation:

  • This report details a rare case of a 46-year-old woman with a malignant phyllodes tumor.
  • The tumor exhibited extensive lipomatous differentiation, a seldom-seen stromal alteration.

Findings:

  • Lipomatous differentiation in malignant phyllodes tumors can manifest as a fat-containing mass on breast imaging.
  • Histopathological examination confirmed the stromal adipose tissue component.

Implications:

  • Recognizing lipomatous differentiation is crucial for accurate diagnosis and treatment planning of phyllodes tumors.
  • This presentation expands the understanding of the diverse histological spectrum of phyllodes tumors.