Engineering of tissue constructs using coaxial bioprinting

Area of Science:

• Biotechnology
• Regenerative Medicine
• Tissue Engineering

Background:

• Bioprinting is a key technology for fabricating biological tissues and organs.
• Coaxial extrusion bioprinting offers enhanced versatility through concentric biomaterial deposition.
• This technique has evolved from simple vasculature to complex constructs with diverse cellular components and functionalities.

Purpose of the Study:

• To review the history and engineering components of coaxial bioprinting.
• To explore recent advancements and future potential in various organ systems.
• To demonstrate how coaxial bioprinting facilitates complex tissue construct creation.

Main Methods:

• Review of historical development and engineering principles of coaxial bioprinting.
• Analysis of current research progress in applying coaxial bioprinting to specific organs and biological systems.
• Synthesis of findings to highlight the role of coaxial bioprinting in tissue fabrication.

Main Results:

• Coaxial bioprinting has advanced significantly, enabling complex tissue constructs with integrated cell composition, self-assembly, ECM patterning, controlled release, and multi-material gradients.
• The technology has evolved from fabricating simple tubular vasculature to sophisticated tissue architectures.
• Significant progress has been made in applying coaxial bioprinting across various biological systems.

Conclusions:

• Coaxial bioprinting is a rapidly advancing technology with substantial potential.
• It significantly enhances the engineering versatility of bioprinting for complex tissue fabrication.
• This technology is poised to make major contributions to in vitro modeling, pharmaceutical development, and clinical regenerative medicine.