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Serum Endocan Levels Predict Angiographic No-Reflow Phenomenon in Patients With ST-Segment Elevation Myocardial

Mustafa Dogdus1, Mustafa Yenercag2, Mehmet Ozyasar3

  • 1Department of Cardiology, Usak University, Training and Research Hospital, Turkey.

Angiology
|September 30, 2020
PubMed

Insights

Elevated endocan levels predict the no-reflow phenomenon (NRP) in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). Higher endocan indicates a greater risk of poor myocardial perfusion.

Area of Science:

  • Cardiology
  • Biomarkers
  • Vascular Biology

Background:

  • The no-reflow phenomenon (NRP) complicates primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI).
  • Endocan, a marker of endothelial dysfunction and inflammation, is secreted by activated vascular endothelium.
  • The association between endocan levels and NRP in STEMI patients remains to be fully elucidated.

Purpose of the Study:

  • To investigate the relationship between serum endocan levels and the occurrence of NRP in STEMI patients undergoing pPCI.
  • To determine if endocan can serve as an independent predictor of NRP.

Main Methods:

  • A cohort of 137 consecutive STEMI patients undergoing coronary angiography and pPCI were enrolled.
  • Clinical characteristics and serum endocan levels were measured for all participants.
  • Statistical analyses, including multivariate analysis, were performed to assess the association between endocan and NRP.

Main Results:

  • Endocan levels were significantly higher in patients with NRP compared to those without NRP (P < .001).
  • Multivariate analysis identified endocan as an independent predictor of NRP (P < .001, OR = 2.39, 95% CI = 1.37-4.15).
  • An endocan level >2.7 ng/mL demonstrated high sensitivity (89.6%) and specificity (74.2%) for predicting NRP (AUC: 0.832, P < .001).

Conclusions:

  • Serum endocan level is an independent predictor of NRP in STEMI patients treated with pPCI.
  • Measuring endocan levels may help identify patients at higher risk for insufficient myocardial perfusion and adverse clinical outcomes.

Keywords:
ST-segment elevation myocardial infarctionendocanno-reflow phenomenon

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