Related Experiment Video

Updated: Dec 7, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Lorlatinib induced proteinuria: A case report

Chung-Shien Lee1,2, Rimda Wanchoo3, Nagashree Seetharamu2

  • 1Department of Clinical Health Professions, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, USA.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|September 30, 2020
PubMed
Abstract

Insights

Lorlatinib, used for non-small cell lung cancer (NSCLC), may cause proteinuria. Reducing the lorlatinib dose improved this side effect, suggesting a dose-dependent relationship.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Lorlatinib is an ALK/ROS1 tyrosine kinase inhibitor for ALK-positive NSCLC.
  • It has excellent CNS penetrability, leading to CNS adverse events.
  • Proteinuria has not been previously reported with lorlatinib.

Observation:

  • A case of lorlatinib-induced proteinuria in a patient with ROS1-rearranged NSCLC is presented.
  • The patient experienced proteinuria while on second-line lorlatinib therapy.

Findings:

  • Proteinuria improved with dose reduction of lorlatinib (100mg to 75mg, then 50mg daily).
  • Other adverse events, including hallucinations and peripheral neuropathy, also improved.

Implications:

  • This case provides evidence of lorlatinib-induced proteinuria.
  • The proteinuria appears to be dose-dependent, suggesting a potential management strategy.
Keywords:
ALKLorlatinibROS1non-small cell lung cancerproteinuria

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