Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open and closed-loop control systems01:17

Open and closed-loop control systems

1.4K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.4K
Classification of Systems-I01:26

Classification of Systems-I

470
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
470
Multiple Pipe Systems01:21

Multiple Pipe Systems

1.0K
Multipipe systems consist of complex configurations of interconnected pipes designed to transport fluids efficiently across intricate networks. They are essential in engineering applications requiring precise control over flow distribution, pressure, and head loss. They are categorized into series, parallel, loop, and network configurations, each distinguished by unique flow characteristics and applications.
Series Configuration
In a series configuration, fluid flows sequentially from one pipe...
1.0K
Feedback control systems01:26

Feedback control systems

589
Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
589
Cyclic Processes And Isolated Systems01:19

Cyclic Processes And Isolated Systems

3.3K
A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
3.3K
Thermodynamic Systems01:06

Thermodynamic Systems

7.2K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of  tea boiling in a kettle. The...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Swiss obesity clinical practice guidance.

Swiss medical weekly·2026
Same author

Beyond the scale: a systems-level reframing of obesity and metabolic care.

Current opinion in clinical nutrition and metabolic care·2026
Same author

Semaglutide-associated Twiddler syndrome.

JCEM case reports·2026
Same author

Accuracy of Continuous Glucose Monitoring in Adults With Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass Surgery Under Stable and Dynamic Glucose Conditions.

Diabetes care·2026
Same author

Diabetes and menopause: A critical yet neglected intersection.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Clinical Efficacy Evaluation of a Continuous Glucose Monitoring-Guided Forecasting Algorithm to Mitigate Postbariatric Hypoglycemia: A Randomized Controlled Trial.

Diabetes technology & therapeutics·2026
Same journal

[Multimodal Cardiac Imaging: New Developments for Clinical Practice].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Coronary angiography: From cardiac catheterization to advanced interventional cardiovascular imaging].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Athlete's heart: role of cardiac imaging in the prevention of sudden cardiac death].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Multimodal imaging in cardiac amyloidosis and cardiac sarcoidosis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Inflammatory Heart Disease: The Role of Multimodality Cardiac Imaging in Myocarditis and Pericarditis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

State-of-the-Art Cardiac Imaging

Therapeutische Umschau. Revue therapeutique·2026
See all related articles

Related Experiment Video

Updated: Dec 7, 2025

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.9K

[Closed-loop systems - Update 2020].

Andreas Melmer1, Afroditi Tripyla1, David Herzig1

  • 1Universitätsklinik für Diabetologie, Endokrinologie, klinische Ernährung und Metabolismus (UDEM), Inselspital, Universitätsspital Bern.

Therapeutische Umschau. Revue Therapeutique
|September 30, 2020
PubMed
Summary
This summary is machine-generated.

Artificial pancreas, or closed-loop systems, improve diabetes management by automating insulin delivery based on continuous glucose monitoring. These systems reduce high and low blood sugar levels and glucose variability compared to traditional methods.

More Related Videos

Closed System Cell Culture Protocol Using HYPERStack Vessels with Gas Permeable Material Technology
11:48

Closed System Cell Culture Protocol Using HYPERStack Vessels with Gas Permeable Material Technology

Published on: November 29, 2010

19.1K
An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
08:44

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

7.6K

Related Experiment Videos

Last Updated: Dec 7, 2025

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.9K
Closed System Cell Culture Protocol Using HYPERStack Vessels with Gas Permeable Material Technology
11:48

Closed System Cell Culture Protocol Using HYPERStack Vessels with Gas Permeable Material Technology

Published on: November 29, 2010

19.1K
An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
08:44

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

7.6K

Area of Science:

  • Endocrinology
  • Biomedical Engineering
  • Diabetes Technology

Background:

  • The artificial pancreas, a closed-loop system, is a significant advancement in diabetes therapy.
  • It utilizes a control algorithm with continuous glucose monitoring to automate insulin delivery.

Purpose of the Study:

  • To review the current state of closed-loop systems in diabetes care.
  • To discuss technical aspects, clinical evidence, and future directions.

Main Methods:

  • Review of clinical studies and technical developments in closed-loop systems since 2011.
  • Analysis of data comparing closed-loop systems with conventional insulin pump therapy.

Main Results:

  • Closed-loop systems improve glucose control by reducing hyperglycemia, hypoglycemia, and glucose variability.
  • The first hybrid-closed-loop system was approved in 2016, though user involvement is still required for mealtime insulin dosing.

Conclusions:

  • Closed-loop systems represent a major step forward in diabetes management.
  • Challenges include the pharmacokinetics of subcutaneous insulin and the need for multiple devices. Future developments aim to overcome these limitations.