Trifunctionalization of alkenes and alkynes
Sumit Ghosh1, Dipti Lai1, Alakananda Hajra1
1Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India. alakananda.hajra@visva-bharati.ac.in.
Organic & Biomolecular Chemistry
|September 30, 2020
Summary
Trifunctionalization efficiently creates complex molecules by adding three functional groups at once. This review details advancements in these synthetic organic chemistry methods for alkenes and alkynes.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Trifunctionalization is a key synthetic strategy for creating complex molecules.
- It allows the concurrent introduction of three functional groups in a single step.
- This method utilizes simple and readily available starting materials.
Purpose of the Study:
- To review the development of trifunctionalization methods.
- To cover methodologies for alkenes, alkynes, arynes, and allenes.
- To highlight recent advancements in the field.
Main Methods:
- Literature review of published trifunctionalization methodologies.
- Focus on methods developed over the last two decades.
- Categorization of methods based on substrate (alkenes, alkynes, etc.).
Main Results:
- Numerous trifunctionalization methods have been developed for various organic systems.
- Significant progress has been made in enhancing the efficiency and scope of these reactions.
- The review consolidates existing knowledge on alkene and alkyne trifunctionalization.
Conclusions:
- Trifunctionalization is a powerful and evolving area in synthetic organic chemistry.
- Continued development of these methods promises greater access to diverse chemical structures.
- This review serves as a comprehensive resource for researchers in the field.
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