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Functional connectivity during smooth pursuit eye movements.

Rebekka Schröder1, Anna-Maria Kasparbauer1, Inga Meyhöfer1

  • 1Department of Psychology, University of Bonn, Bonn, Germany.

Journal of Neurophysiology
|September 30, 2020
PubMed
Summary
This summary is machine-generated.

Smooth pursuit eye movements (SPEM) involve visual, parietal, and frontal brain areas. This study found these areas connect extensively, but connectivity didn't change with target motion frequency, despite performance declines.

Keywords:
eye movementsfMRIfunctional connectivitypsychophysiological interactionssmooth pursuit

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Smooth pursuit eye movements (SPEM) are crucial for maintaining visual focus on moving objects.
  • The neural network for SPEM involves visual, parietal, and frontal brain regions.
  • Understanding functional connectivity within this network is key, especially given SPEM's potential as an endophenotype for psychoses.

Purpose of the Study:

  • To investigate the functional coupling of brain areas involved in SPEM.
  • To determine how target motion frequency influences this functional connectivity.
  • To analyze the relationship between specific eye movement-related seed regions and broader brain activity during SPEM.

Main Methods:

  • Simultaneous recording of eye movements and blood oxygen level-dependent (BOLD) activity in 57 healthy participants.
  • Analysis of functional connectivity using a psychophysiological interaction (PPI) approach.
  • Examination of seed regions including LGN, V1, V5, PPC, and FEF.

Main Results:

  • SPEM performance declined significantly at higher target frequencies (0.4 Hz vs. 0.2 Hz).
  • BOLD activity revealed a widespread geniculo-occipito-parieto-frontal network during SPEM.
  • Frontal eye fields and posterior parietal cortex showed extensive task-dependent connectivity, while other regions had more localized connections.

Conclusions:

  • The study confirms and expands knowledge of the neural mechanisms underlying SPEM.
  • Key oculomotor regions exhibit robust functional connectivity with each other and other cortical areas.
  • While higher target frequencies increased visual activation, they did not alter functional connectivity patterns, suggesting distinct neural processes.