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Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2 and Amines

Yulei Zhao1, Xuqiang Guo1, Zhiyao Si1

  • 1School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

The Journal of Organic Chemistry
|September 30, 2020
PubMed

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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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Alkylation is one of the methods used to prepare amines. Direct alkylation of ammonia or a primary amine with an alkyl halide gives polyalkylated amines along with a quaternary ammonium salt through successive SN2 reactions. This process of making the quaternary salt through the direct alkylation method is called exhaustive alkylation.
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