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Related Experiment Video

Updated: Dec 7, 2025

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Published on: March 4, 2015

Molecular Ultrasound Imaging.

Gurbet Köse¹, Milita Darguzyte¹, Fabian Kiessling^1,2

¹Institute for Experimental Molecular Imaging, University Hospital Aachen, Forckenbeckstrasse 55, 52074 Aachen, Germany.

Nanomaterials (Basel, Switzerland)

|October 1, 2020

Summary

Molecular ultrasound imaging advances disease diagnosis by visualizing intravascular targets. This review covers detection technologies, targeted microbubbles, and clinical translation progress for improved disease characterization.

Keywords:

active targeting angiogenesis clinical translation inflammation molecular imaging molecular ultrasound nanobubbles targeted microbubbles thrombosis

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Area of Science:

Medical Imaging
Biotechnology
Nanotechnology

Background:

Molecular ultrasound imaging has rapidly advanced in the past decade.
It shows promise for diagnosing angiogenesis, inflammation, and thrombosis.
Intravascular targets like VEGFR2, integrins, and selectins have been visualized in vivo.

Purpose of the Study:

To review recent progress in molecular ultrasound imaging.
To introduce relevant detection technologies and targeted microbubble concepts.
To highlight applications in disease characterization and clinical translation.

Main Methods:

Review of current molecular ultrasound imaging techniques.
Discussion of sensitive particle acoustic quantification (SPAQ), destruction-replenishment analysis, and dwelling time assessment.
Exploration of microbubble echogenicity changes and radiation force ultrasound applications.

Main Results:

Pre-clinical studies show increased sensitivity and specificity compared to conventional ultrasound.
Targeted microbubbles are being developed for in vivo visualization of disease markers.
Two targeted microbubble formulations are in clinical trials for tumor and liver lesion detection.

Conclusions:

Molecular ultrasound imaging offers enhanced disease detection, classification, and therapy monitoring.
Significant progress has been made in targeted microbubble development and detection technologies.
Clinical translation is advancing, but challenges remain in widespread adoption.