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Updated: Dec 7, 2025

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Which is the Best Option in Calcified Leaflets? MitraClip NTR or XTR?

Shu-I Lin1, Maurizio Taramasso, Mizuki Miura

  • 1University Heart Center Zurich, University Hospital of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland. yardbird881@gmail.com.

The Journal of Invasive Cardiology
|October 1, 2020
PubMed

Insights

Choosing the right clip size for transcatheter edge-to-edge repair remains difficult. The XTR clip shows superior outcomes compared to the NTR clip for calcified mitral valve leaflets.

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Medical device technology

Background:

  • Transcatheter edge-to-edge repair (TEER) is a minimally invasive treatment for mitral regurgitation.
  • Accurate sizing of TEER devices is crucial for successful outcomes.
  • Calcified leaflets present unique challenges in TEER procedures.

Observation:

  • The selection of appropriate clip size is a significant challenge in current TEER practices.
  • The study compared the performance of the XTR clip versus the NTR clip in patients with calcified mitral valve leaflets.

Findings:

  • The XTR clip demonstrated a better clinical outcome compared to the NTR clip in the context of calcified leaflets.
  • This suggests specific device advantages for complex leaflet morphologies.

Implications:

  • The findings may guide optimal device selection in TEER for calcified mitral valves.
  • Further research could explore the broader applicability of the XTR clip in challenging anatomical cases.
  • This contributes to the evolving landscape of structural heart interventions.

Keywords:
MitraClip implantationcalcified leafletmitral regurgitation

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