[Characteristics of mRNA and cDNA of fructose-1,6-diphosphate aldolase]

Problems concerning synthesis of fructose-1,6-diphosphataldolase A (EC 4.1.2.13) in vitro, and localization in a cell and sizes of mRNA of this enzyme are considered in the review. The following items are described: methods for production and properties of individual mRNA and cDNA of the aldolase isoenzymes; making of the amino acid sequence of the aldolase isoenzyme forms according to the nucleotide sequence of mRNA and cDNA and peculiarities of isoform structure in different tissues of animals; structure of mRNA and cDNA of FDP-aldolase in the norm and under pathology and mechanisms of the appearance of nonspecific enzyme isoforms. Regulation of protein biosynthesis under pathology is considered as exemplified by mRNA and cDNA of FDP-aldolase.