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Suspected Gentamicin-Induced Retinal Vascular Occlusion after Vitrectomy
Fumiko Murao1, Takamasa Kinoshita2, Takashi Katome1
1Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Case Reports in Ophthalmology
|October 1, 2020
Summary
Gentamicin injections after eye surgery may cause retinal vascular occlusions. This rare complication, involving retinal artery and vein blockages, occurred in two patients post-vitrectomy.
Area of Science:
- Ophthalmology
- Retinal Vascular Diseases
- Ocular Surgery Complications
Background:
- Retinal vascular occlusion is a rare but serious complication following ocular surgery.
- Potential causes include cardiovascular disease, anesthesia, high intraocular pressure, and drug toxicity.
Observation:
- Two cases of multiple retinal vascular occlusions are presented after uncomplicated 25-gauge vitrectomy.
- Both patients received a subconjunctival injection of gentamicin at the conclusion of surgery.
- Clinical observations included retinal hemorrhages, macular whitening, and cotton wool spots.
Findings:
- The primary suspected cause of retinal vascular occlusion in both cases was the subconjunctival gentamicin injection.
- The occlusions affected both retinal arteries and veins, leading to macular ischemia.
Implications:
- This report highlights a potential iatrogenic cause of retinal vascular occlusion.
- Caution is advised regarding the use of subconjunctival gentamicin in ocular surgery.
- Further investigation into the link between gentamicin and retinal vascular events is warranted.
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