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The authors' response.

Ofer Sadan1, Owen Samuels1

  • 1Department of Neurology and Neurosurgery, Division of Neurocritical Care, Emory University Hospital, 1364 Clifton Rd. NE, Atlanta, GA 30322 USA.

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|October 1, 2020
PubMed
Summary
This summary is machine-generated.

This pilot study found that a 16.4% NaCl/Na-acetate solution was safe and feasible, potentially reducing acute kidney injury (AKI). Further large randomized controlled trials are needed to confirm these findings and explore chloride

Keywords:
Acute kidney injuryCerebral edemaHyperchloremiaHyperosmolar therapyNeurocritical careSubarachnoid hemorrhage

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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Fluid and Electrolyte Balance

Background:

  • Acute kidney injury (AKI) is a significant clinical challenge.
  • The role of chloride in AKI pathogenesis is an area of ongoing investigation.
  • Current treatment strategies for AKI require further optimization.

Purpose of the Study:

  • To evaluate the feasibility and safety of administering a 16.4% NaCl/Na-acetate solution.
  • To explore the potential of this solution in reducing AKI rates.
  • To provide preliminary data for future large-scale randomized controlled trials (RCTs).

Main Methods:

  • A pilot study design was employed.
  • The study involved the administration of a 16.4% NaCl/Na-acetate solution.
  • Feasibility, safety, and AKI rates were monitored.

Main Results:

  • The administration of the 16.4% NaCl/Na-acetate solution was demonstrated to be feasible and safe.
  • The study observed lower rates of AKI associated with this intervention.
  • The results support the potential utility of this solution in AKI prevention or management.

Conclusions:

  • This pilot study provides preliminary evidence for the safety and feasibility of using a 16.4% NaCl/Na-acetate solution.
  • The findings suggest a potential benefit in reducing AKI rates.
  • Larger RCTs are warranted to validate these results and elucidate the role of chloride in AKI.