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Targeting senescent cells and tumor therapy (Review)
Zehua Wang1, Jianwen Gao2, Haiou Liu1
1Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, P.R. China.
International Journal of Molecular Medicine
|October 1, 2020
Summary
Cell senescence, a state of irreversible cell cycle arrest, contributes to aging and disease. Clearing senescent cells shows promise for treating age-related conditions and improving lifespan.
Area of Science:
- Gerontology and Cellular Biology
- Molecular Biology and Aging Research
Background:
- Cell senescence is a state of stable cell cycle arrest driven by cellular damage.
- Senescent cells exhibit altered morphology, metabolism, and resistance to apoptosis, accumulating in tissues.
- These cells secrete inflammatory factors, creating microenvironments that promote organ degeneration and age-related diseases.
Purpose of the Study:
- To review recent advancements in senescent cell clearance strategies.
- To discuss the role of cell senescence in aging and associated diseases.
- To explore the therapeutic potential of targeting senescent cells for anti-aging interventions.
Main Methods:
- Literature review of recent studies on senescent cell clearance.
- Analysis of the mechanisms underlying cell senescence.
- Examination of the link between senescence, aging, and disease pathology.
Main Results:
- Accumulation of senescent cells drives aging and age-related diseases.
- Targeted elimination of senescent cells can delay disease onset and improve healthspan.
- Senescence plays a complex role in tumor therapy, with potential dual effects.
Conclusions:
- Targeting senescent cells offers a promising therapeutic strategy for age-related diseases.
- Further research is needed to optimize senescent cell clearance and understand its limitations.
- Senescent cell targeting holds potential for improving patient lifespan and quality of life.
