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Updated: Aug 9, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
[Biologically active metabolites of membrane glycerophospholipids in normal conditions and in pathologic states]
Abstract:
The data on biological role of numerous phospholipid metabolites, main part of which is localized in cell membranes, are reviewed. Many of these metabolites are related to slowly reacting substances of anaphylaxis and participate in allergic and inflammatory reactions. Conditions of biosynthesis of phospholipid active metabolites are characterized in the reactions of lipid peroxidation, N-acetylation, formation of Shiff bases, enaminales via transacetylation, by the action of phospholipases, lipooxygenase, cyclooxygenase, by formation of plasmalogens, phosphomonolipids, phospholipid diols. Role of individual phospholipid metabolites in normal and pathological states is discussed.
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