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Updated: Dec 7, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Polysulfuration via a Bilateral Thiamine Disulfurating Reagent
Jiahui Xue1, Xuefeng Jiang1,2
1Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China.
A new method efficiently builds polysulfides using a thiamine disulfurating reagent. This process generates diverse trisulfides and tetrasulfides under mild conditions, offering a versatile synthetic strategy.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
- Sulfur Chemistry
Background:
- Polysulfides are crucial in various chemical applications.
- Efficient synthesis of unsymmetrical polysulfides remains a challenge.
Purpose of the Study:
- To develop an efficient method for polysulfide construction.
- To synthesize diverse unsymmetrical trisulfides and tetrasulfides.
Main Methods:
- Utilized a bilateral six-membered thiamine disulfurating reagent.
- Leveraged ring strain energy for controlled sulfur-sulfur bond formation.
- Employed nucleophilic assembly on the sulfur-sulfur motif.
Main Results:
- Achieved efficient polysulfide construction.
- Generated a variety of unsymmetrical trisulfides and tetrasulfides.
- Demonstrated high efficiency, mild reaction conditions, and broad substrate scope.
Conclusions:
- The developed moduling disulfuration is a highly effective strategy for synthesizing unsymmetrical polysulfides.
- This method offers a mild and versatile approach for accessing complex sulfur-containing molecules.
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Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Conversion of Alcohols to Alkyl Halides
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