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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Updated: Dec 7, 2025

Murine Model of Allergen Induced Asthma
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Asthma-associated risk for COVID-19 development.

Chrysanthi Skevaki1, Antonina Karsonova2, Alexander Karaulov2

  • 1Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany; German Center for Lung Research (DZL), Marburg, Germany.

The Journal of Allergy and Clinical Immunology
|October 1, 2020
PubMed
Summary
This summary is machine-generated.

Patients with asthma may have varying risks for severe coronavirus disease 2019 (COVID-19). Different asthma types, like type 2 versus non-type 2, could influence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection outcomes.

Keywords:
COVID-19SARS-CoV-2asthmaendotypesnon–type 2 asthmatype 2 asthma

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Area of Science:

  • * Pulmonology and Infectious Diseases
  • * Epidemiology and Clinical Research

Background:

  • * Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the COVID-19 pandemic, with comorbidities like hypertension and diabetes increasing patient risk.
  • * The association between bronchial asthma and COVID-19 is controversial and shows regional variations.
  • * Asthma, a prevalent chronic inflammatory lung disease, affects airways targeted by SARS-CoV-2, prompting investigation into their clinical and pathophysiological links.

Purpose of the Study:

  • * To analyze the global epidemiology of asthma in COVID-19 patients.
  • * To propose a concept linking asthma endotypes to differential COVID-19 risk profiles.
  • * To explore the implications for future COVID-19 diagnostics and therapies.

Main Methods:

  • * Global epidemiological data analysis of asthma patients with COVID-19.
  • * Conceptual framework development based on existing literature and data.
  • * Comparative risk assessment across different asthma endotypes.

Main Results:

  • * Preliminary analysis suggests varying risks associated with asthma and COVID-19.
  • * Different asthma endotypes (type 2 vs. non-type 2) may present distinct risk profiles for SARS-CoV-2 infection and COVID-19 severity.
  • * Regional differences in asthma prevalence and COVID-19 outcomes are noted.

Conclusions:

  • * The concept of asthma endotypes influencing COVID-19 risk warrants further investigation.
  • * Understanding these differences can refine risk stratification for asthma patients.
  • * This framework may guide the development of targeted COVID-19 diagnostics and immune-based therapies.