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Therapeutic aspects of the Axl/Gas6 molecular system
Rossella Di Stasi1, Lucia De Rosa1, Luca D D'Andrea2
1Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy.
Abstract:
Axl receptor tyrosine kinase (RTK) and its ligand, growth arrest-specific protein 6 (Gas6), are involved in several biological functions and participate in the development and progression of a range of malignancies and autoimmune disorders. In this review, we present this molecular system from a drug discovery perspective, highlighting its therapeutic implications and challenges that need to be addressed. We provide an update on Axl/Gas6 axis biology, exploring its role in fields ranging from angiogenesis, cancer development and metastasis, immune response and inflammation to viral infection. Finally, we summarize the molecules that have been developed to date to target the Axl/Gas6 molecular system for therapeutic and diagnostic applications.
Insights
The Axl/Gas6 molecular system is crucial in cancer and autoimmune diseases. Targeting this axis offers therapeutic potential but faces challenges in drug development.
Area of Science:
- Molecular Biology
- Drug Discovery
- Oncology
Background:
- The Axl receptor tyrosine kinase (RTK) and its ligand, growth arrest-specific protein 6 (Gas6), play significant roles in various biological processes.
- Dysregulation of the Axl/Gas6 axis is implicated in the pathogenesis of numerous cancers and autoimmune disorders.
Purpose of the Study:
- To review the Axl/Gas6 molecular system from a drug discovery viewpoint.
- To highlight therapeutic implications and challenges associated with targeting the Axl/Gas6 axis.
- To provide an updated overview of Axl/Gas6 axis biology and its diverse roles.
Main Methods:
- Literature review of Axl/Gas6 axis biology.
- Analysis of therapeutic strategies targeting the Axl/Gas6 pathway.
- Summary of current drug candidates for Axl/Gas6 modulation.
Main Results:
- The Axl/Gas6 axis is involved in critical cellular functions including angiogenesis, cancer progression, metastasis, immune response, inflammation, and viral infections.
- Several molecular entities have been developed to target the Axl/Gas6 system.
- Therapeutic and diagnostic applications are being explored for Axl/Gas6-targeting agents.
Conclusions:
- The Axl/Gas6 axis represents a promising target for therapeutic intervention in various diseases.
- Further research and development are needed to overcome challenges in Axl/Gas6-targeted drug discovery.
- Targeting the Axl/Gas6 pathway holds potential for novel treatments in oncology, immunology, and infectious diseases.
