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Updated: Dec 7, 2025
09:43
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
Published on: August 10, 2015
16.4K
Precision renal replacement therapy.
Zaccaria Ricci1, Ashita Tolwani2, Nuttha Lumlertgul3,4,5,6
1Department of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza S.Onofrio 4, Rome, Italy.
Current Opinion in Critical Care
|October 1, 2020
Summary
Precision medicine tailors acute renal replacement therapy (RRT) for critically ill patients. Individualized timing, solute control, anticoagulation, and technology enhance RRT delivery for better patient outcomes.
Area of Science:
- Nephrology
- Critical Care Medicine
- Translational Medicine
Background:
- Acute renal replacement therapy (RRT) is a complex intervention for critically ill patients.
- Optimizing RRT delivery requires personalized approaches.
Purpose of the Study:
- To review evidence for precision medicine in acute RRT for critically ill patients.
- Focus areas include timing, solute control, anticoagulation, and technological advancements.
Main Methods:
- Review of current evidence on precision medicine applications in RRT.
- Analysis of factors influencing RRT initiation, dosing, anticoagulation, and technology.
Main Results:
- Precision medicine is most applicable to RRT timing, guided by patient characteristics and logistics.
- Dynamic dialytic dosing and individualized anticoagulation (e.g., regional citrate anticoagulation) are key.
- Technological innovations enhance RRT accuracy and efficiency.
Conclusions:
- Precision medicine allows for tailored RRT prescriptions in critically ill patients.
- Individualized strategies in timing, dosing, anticoagulation, and technology improve RRT delivery.
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