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Treatment of urinary tract infection with norfloxacin. Analysis of cost

C Ramirez-Ronda, M Colon, S Saavedra

    The American Journal of Medicine
    |June 26, 1987
    PubMed

    Insights

    Norfloxacin effectively treated urinary tract infections in most patients, including those with complicated cases. This fluoroquinolone antibacterial may be a cost-effective option for infections caused by multiresistant bacteria.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Urology

    Background:

    • Urinary tract infections (UTIs) are common, with increasing resistance to antibiotics.
    • Complicated UTIs often require broad-spectrum antibacterial agents.
    • Norfloxacin is an oral fluoroquinolone with a wide spectrum of activity.

    Purpose of the Study:

    • To evaluate the efficacy and cost-effectiveness of norfloxacin in treating patients with urinary tract infections.
    • To compare norfloxacin treatment with alternative therapies based on susceptibility testing.

    Main Methods:

    • A study involving 25 patients diagnosed with urinary tract infections.
    • Treatment with norfloxacin, an oral fluoroquinolone antibacterial.
    • Evaluation of treatment outcomes and direct costs of alternative therapies.

    Main Results:

    • Of 22 evaluable patients, 20 had complicated UTIs.
    • Norfloxacin successfully cured the infection in 19 out of 22 patients one week post-treatment.
    • Direct costs for alternative treatments varied significantly, ranging from $7 to $970.

    Conclusions:

    • Norfloxacin demonstrated high efficacy in treating urinary tract infections, including complicated cases.
    • Norfloxacin therapy may be a cost-effective choice for UTIs caused by multiresistant bacteria.
    • Individualized alternative treatments were considered alongside norfloxacin therapy.

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