A Deep Brain Stimulation Trial Period for Treating Chronic Pain

Area of Science:

• Neurosurgery
• Neurology

Background:

• Historically, deep brain stimulation (DBS) utilized temporary externalized electrodes for efficacy trials before permanent implantation.
• Established targets for conditions like Parkinson's disease led to a decline in trial periods.
• Modern resurgence driven by exploration of new indications and adaptive DBS technologies.

Purpose of the Study:

• To review approaches, benefits, and risks of inpatient DBS trial periods.
• To focus on the development of new DBS therapies for chronic pain.

Main Methods:

• Literature review of deep brain stimulation trial periods.
• Analysis of historical and current practices.
• Focus on peri-surgical neurophysiological recordings for adaptive DBS.

Main Results:

• DBS trial periods are valuable for identifying new targets in conditions like depression and chronic pain.
• Adaptive DBS necessitates neurophysiological recordings, often performed during peri-surgical periods.
• Inpatient trials offer a structured environment for evaluating stimulation efficacy and safety.

Conclusions:

• Inpatient DBS trial periods are crucial for advancing novel DBS therapies, particularly for chronic pain.
• The resurgence of trial periods supports the development of adaptive DBS and exploration of new neurological targets.
• Careful consideration of approaches, benefits, and risks is essential for successful implementation.