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Updated: Dec 7, 2025

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation
Frederick Guzman1, Yasamin Fazeli2, Meagan Khuu2
1Department of Pharmaceutical Sciences, University of California, 101 Theory #100, Irvine, CA 92617, USA.
Abstract:
Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to regulate transcription of cell cycle progression genes, pRB can remodel chromatin to exert several of its other biological roles. In this review, we discuss the diverse functions of pRB in epigenetic regulation including nucleosome mobilization, histone modifications, DNA methylation and non-coding RNAs.
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