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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Asthma-II: Pathophysiology and Classification01:26

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic dermatitis.

Elena Galli1, Bianca Cinicola2, Rossella Carello1

  • 1UOS Immuno Allergologia dell'Età evolutiva, Ospedale San Pietro-Fatebenefratelli, Roma, Italy. galli.elena@fbfrm.it.

Acta Bio-Medica : Atenei Parmensis
|October 2, 2020
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) is a complex skin disease affecting all ages. Understanding its multifactorial causes is key to developing new, curative treatments beyond current symptom management.

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Area of Science:

  • Dermatology
  • Immunology
  • Microbiome research

Background:

  • Atopic dermatitis (AD) is a prevalent inflammatory skin condition with recurrent eczema and itching.
  • While often starting in infancy, AD affects adults and involves genetic, environmental, and immunological factors.
  • AD pathogenesis is now understood as a complex interplay of epidermal barrier dysfunction, immune dysregulation, and microbiome alterations.

Purpose of the Study:

  • To review the complex etiology and pathogenesis of atopic dermatitis.
  • To highlight the significant psycho-social and economic burden of AD.
  • To emphasize the need for deeper understanding to develop curative therapies.

Main Methods:

  • Literature review of atopic dermatitis etiology and pathogenesis.
  • Analysis of current understanding of immune, barrier, and microbiome roles.
  • Examination of clinical characteristics and patient impact.

Main Results:

  • AD etiology is multifactorial, involving genetic predisposition, environmental factors, barrier defects, microbiome changes, and immune dysregulation.
  • The disease is recognized as a lifelong condition with variable expression, impacting skin health and increasing risks for other disorders.
  • Current treatments focus on symptom management, but curative options require further research into AD's complex mechanisms.

Conclusions:

  • Atopic dermatitis is a complex, lifelong condition with significant patient burden.
  • A comprehensive understanding of AD pathogenesis, including immune, barrier, and microbiome interactions, is crucial.
  • Future research into the heterogeneity of AD is essential for developing novel, curative treatments.