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Area of Science:

  • Toxicology
  • Cardiovascular Physiology
  • Developmental Biology

Background:

  • Food colorings are widely used but may pose health risks.
  • Zebrafish (Danio rerio) are valuable model organisms for toxicity screening due to their transparency and genetic similarity to humans.
  • Microfluidic technology offers advanced capabilities for zebrafish manipulation and imaging in drug discovery.

Purpose of the Study:

  • To design and develop a microfluidic detection platform for zebrafish larvae.
  • To investigate the effects of food colorings (Cochineal Red and Brilliant Blue FCF) on cardiovascular functionality and pectoral fin swing ability in zebrafish.
  • To assess the potential of microfluidics for high-throughput toxicity screening using zebrafish.

Main Methods:

  • Development of a microfluidic platform for zebrafish larvae manipulation and imaging.
  • Exposure of zebrafish embryos to Cochineal Red and Brilliant Blue FCF at concentrations of 0.02‰ and 0.2‰.
  • Assessment of cardiovascular parameters (heart rate, cardiac output) and pectoral fin swing behavior.
  • Visualization of induced flow fields to analyze swimming behavior.

Main Results:

  • Cochineal Red (0.2‰) significantly altered pectoral fin swing behavior and increased heart rate in juvenile zebrafish.
  • Brilliant Blue FCF (0.2%) elevated heart rate during early embryonic stages.
  • No significant changes in cardiac output were observed in zebrafish exposed to food colorings.
  • Microfluidic platform enabled visualization of behavioral changes and physiological responses.

Conclusions:

  • Food colorings can induce significant physiological and behavioral changes in zebrafish larvae.
  • The developed microfluidic platform is effective for in-vivo toxicity screening of food dyes.
  • This technology holds promise for broader applications in drug testing and neurobiological studies using zebrafish.