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Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Updated: Dec 7, 2025

Enhancing Tumor Content through Tumor Macrodissection

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Published on: February 12, 2022

Primary CD20-positive mediastinal diffuse large B-cell lymphoma.

Wulyo Rajabto¹, Dimas Priantono¹

¹Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia Jakarta Indonesia.

Respirology Case Reports

|October 2, 2020

Summary

This summary is machine-generated.

Primary mediastinal B-cell lymphoma (PMBCL) presents unique diagnostic challenges. Early R-DA-EPOCH chemotherapy in a young patient led to a successful outcome, highlighting the importance of timely and appropriate treatment.

Keywords:

CD20‐positive DLBCL lymphoma mediastinal

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Area of Science:

Hematology
Oncology
Pathology

Background:

Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of lymphoma.
Its unique characteristics can lead to delayed diagnosis and management.
Differentiating PMBCL from diffuse large B-cell lymphoma (DLBCL) is crucial for effective treatment.

Observation:

A 22-year-old presented with dyspnea, weight loss, and night sweats.
Elevated lactate dehydrogenase (LDH) and a large mediastinal mass on CT scan were noted.
Diagnosis was confirmed via CT-guided core biopsy with pathological and immunohistochemical analysis.

Findings:

The patient was diagnosed with primary mediastinal B-cell lymphoma.
Treatment with Rituximab Dose-Adjusted Etoposide Prednisolone Vincristine Cyclophosphamide Doxorubicin (R-DA-EPOCH) resulted in a positive response.
This case underscores the diagnostic complexities and therapeutic considerations for PMBCL.

Implications:

Accurate differentiation of PMBCL from DLBCL is essential to avoid suboptimal treatment strategies.
Prompt and appropriate systemic therapy, particularly R-DA-EPOCH, can lead to excellent outcomes in young, low-risk patients.
This case highlights the importance of specialized diagnosis and tailored treatment for rare lymphomas.