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Related Concept Videos

Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Bioartificial Kidneys.

Peter R Corridon1,2,3, In Kap Ko1, James J Yoo1

  • 1Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA.

Current Stem Cell Reports
|October 2, 2020
PubMed
Summary
This summary is machine-generated.

Bioartificial kidneys offer a promising alternative to traditional dialysis for kidney disease treatment. Advances in bioengineering are paving the way for novel renal technologies to restore kidney function.

Keywords:
BioengineeringBioratificial kidneyCell therapy and gene therapyDialysisRegenerative medicine

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nephrology

Background:

  • Hemodialysis remains the standard for kidney disease treatment but faces challenges due to rising prevalence and limited understanding of disease causes.
  • There is a critical need for improved treatments for kidney diseases, especially for patients ineligible for transplants.
  • Current clinical management regimens are burdened by the increasing global incidence of kidney diseases.

Purpose of the Study:

  • To review research efforts in developing bioartificial kidneys as alternatives to conventional dialysis.
  • To explore advancements in genomic, cellular, and tissue engineering for improved bioartificial kidney design.
  • To outline the transition from conventional dialysis to novel bioengineered renal technologies.

Main Methods:

  • Review of current research in regenerated organs and implantable constructs for kidney disease.
  • Analysis of advancements in bioengineering, including genomic, cellular, and tissue engineering.
  • Exploration of the integration of living cellular and tissue functions into artificial kidney systems.

Main Results:

  • Bioartificial kidneys incorporate living cellular and tissue functions to better mimic natural kidney processes.
  • Recent technological advancements are enabling the improved design of bioartificial kidney systems.
  • Research is progressing in the development of regenerated organs, implantable constructs, and whole bioengineered kidneys.

Conclusions:

  • Bioartificial renal technologies hold the potential to restore or reintroduce essential kidney functions.
  • These advancements offer practical treatment options for kidney diseases, potentially preventing disease progression.
  • Pioneering efforts in bioengineering aim to provide viable alternatives to conventional dialysis for kidney failure patients.