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Updated: Dec 7, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Small molecule induced toxic human-IAPP species characterized by NMR
Sarah J Cox1, Diana C Rodriguez Camargo, Young-Ho Lee
1Department of Chemistry, University of Michigan, Ann Arbor, MI, USA. ramamoor@umich.edu.
Abstract:
In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-β1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.

