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Medications Available for Weight Reduction in Elective Total Joint Arthroplasty
Derek F Amanatullah1, Levonti Ohanisian, Rami Bailony
11Stanford Hospital and Clinics, Redwood City, California 2Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 3Enara Health, San Mateo, California.
JBJS Reviews
|October 2, 2020
Summary
Elevated body mass index increases arthroplasty complication risks. Preoperative weight loss using anti-obesity medications may optimize surgical outcomes and patient recovery.
Area of Science:
- Orthopaedic surgery
- Bariatric medicine
- Pharmacology
Background:
- Arthroplasty in obese patients is linked to higher rates of reoperation, instability, revision, and infection.
- Preoperative weight reduction is a strategy to mitigate surgical complications.
- Lifestyle changes and anti-obesity medications are options for preoperative weight management.
Purpose of the Study:
- To review the role of anti-obesity medications in optimizing patients for arthroplasty.
- To discuss the potential benefits of preoperative weight loss on surgical outcomes.
Main Methods:
- Review of current literature on anti-obesity medications and their application in surgical optimization.
- Identification of FDA-approved anti-obesity medications relevant to preoperative weight management.
Main Results:
- Six anti-obesity medications are approved by the U.S. Food and Drug Administration (FDA): phentermine, orlistat, phentermine with topiramate extended release (ER), lorcaserin, sustained release (SR) naltrexone with bupropion, and liraglutide.
- These medications offer pharmacological options for patients to achieve preoperative weight loss.
Conclusions:
- Anti-obesity medications represent a potential tool for optimizing patients before arthroplasty.
- Utilizing these medications may lead to improved postoperative recovery and reduced complication rates.
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