Related Experiment Video
Updated: Dec 7, 2025
10:42
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
17.1K
Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis
Geneviève Rioux1,2, Zainab Ridha1, Mélissa Simard1,2
1Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC G1J 1Z4, Canada.
Genes
|October 3, 2020
Summary
This review explores gene expression in psoriasis, focusing on keratinocytes and using transcriptome analysis to identify new biomarkers and therapeutic targets for this inflammatory skin disease.
Area of Science:
- Dermatology
- Genomics
- Molecular Biology
Background:
- Psoriasis is an immune-mediated inflammatory skin disease with complex genetic and environmental causes.
- Understanding genomic alterations is key to developing precise therapies.
- Gene expression analysis, particularly of mRNA transcripts, offers insights into psoriasis onset.
Purpose of the Study:
- To review findings on keratinocyte contributions to psoriasis pathogenesis.
- To summarize studies analyzing psoriatic transcriptomes.
- To highlight the utility of transcriptomic data and 3D skin models in psoriasis research.
Main Methods:
- Review of existing literature on psoriatic transcriptomes.
- Analysis of gene expression data from microarray and RNA sequencing (RNA-seq) studies.
- Examination of data from 3D reconstructed psoriatic skin models.
Main Results:
- Keratinocytes play a significant role in psoriasis pathogenesis.
- Transcriptome analyses reveal altered mRNA expression patterns in psoriatic skin.
- 3D psoriatic skin models are valuable for transcriptomic investigations.
Conclusions:
- Gene expression profiling provides crucial insights into psoriasis.
- Transcriptome analysis aids in discovering novel biomarkers and therapeutic targets.
- Further research using advanced transcriptomic techniques and models can improve psoriasis treatment outcomes.
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