Related Experiment Video
Updated: Dec 7, 2025

08:18
Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
502
Orbital disease in neuro-ophthalmology
Jenny C Dohlman1, Dean M Cestari1,2, Suzanne K Freitag1,3
1Department of Ophthalmology.
Current Opinion in Ophthalmology
|October 3, 2020
Summary
Recent advances enhance understanding and treatment of orbital diseases, including thyroid eye disease and tumors. New therapies and diagnostic methods improve patient outcomes and prevent vision loss.
Area of Science:
- Ophthalmology
- Neurology
- Rheumatology
Background:
- Orbital diseases encompass diverse pathologies causing neuro-ophthalmic issues.
- Understanding these conditions is crucial for managing patient morbidity.
Purpose of the Study:
- To review recent advancements in orbital diseases.
- Focus on thyroid eye disease, myositis, IgG4-related disease, sarcoidosis, granulomatosis with polyangiitis, and tumors.
Main Methods:
- Literature review of recent studies on orbital diseases.
- Synthesis of findings on pathophysiology, diagnosis, and treatment.
Main Results:
- Thyroid eye disease: steroid-sparing therapies, objective monitoring, and environmental factors.
- Optic nerve disease: improved monitoring and prevention of vision loss.
- Orbital tumors: advances in histopathology and classification systems.
Conclusions:
- Orbital diseases cause significant morbidity via neuro-ophthalmic manifestations.
- Improved understanding of orbital disease subtypes enhances treatment strategies.
Related Concept Videos
Glaucoma: Overview
1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Open Angle Glaucoma: Treatment
861
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
861
Angle Closure Glaucoma: Treatment
987
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
987
Accessory Structures of the Eye
3.0K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
3.0K
Photoreceptors and Visual Pathways
8.2K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.2K
Anatomy of the Eyeball
9.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
9.1K

